Human R-Spondin 3 / RSPO3 Protein, Fc Tag, Unconjugated
Biozol Catalog Number:
ABS-RS3-H5253-1MG
Supplier Catalog Number:
RS3-H5253-1mg
Alternative Catalog Number:
ABS-RS3-H5253-1MG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
RSpondin 3 (RSPO3) is also called cysteinerich and single thrombospondin domain containing1 (CRISTIN1), Protein with TSP type1 repeat (PWTSR), is a member of the Rspondin protein family. Rspondins (RSPO) are a recently discovered secretory protein family with four members in human and mouse. Although all four RSPO proteins activate the canonical Wnt pathway, RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. RSPO3 is expressed ubiquitously and expressed at higher level in placenta, small intestine, fetal thymus and lymph node. RSPO3 is the activator of the betacatenin signaling cascade, leading to TCFdependent gene activation. RSPO3 acts both in the canonical Wnt/betacatenindependent pathway and in noncanonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. RSPO3 also acts as a ligand for frizzled FZD8 and LRP6 and may negatively regulate the TGFbeta pathway. - Proteine/Peptide
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Purity:
90%
Form:
Powder
Target:
R-Spondin 3
Immobilized Human R-Spondin 3 Protein, Fc Tag (Cat. No. RS3-H5253) at 5 µg/mL (100 µL/well) can bind Human LGR4, His Tag (Cat. No. LG4-H52H3) with a linear range of 0.02-0.625 µg/mL (QC tested).
Human R-Spondin 3 Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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