Human R-Spondin 1 / RSPO1 (21-146) Protein, His Tag, premium grade, Unconjugated
Biozol Catalog Number:
ABS-RS6-H4220-20UG
Supplier Catalog Number:
RS6-H4220-20ug
Alternative Catalog Number:
ABS-RS6-H4220-20UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
Rspondin1 is also known as Roof platespecific Spondin 1 (RSPO1) and cysteinerich and single thrombospondin domain containing protein 3 (Cristin 3), which is a secreted protein which belongs to the RSpondin family and encodes a secreted activator protein with two cysteinrich, furinlike domains and one thrombospondin type 1 domain. All Rspondins regulate Wnt/betacatenin signaling, but have distinct expression patterns. Like other RSpondins, RSpondin1 contains two adjacent cysteinerich furinlike domains (aa 34135) with one potential Nglycosylation site, followed by a thrombospondin (TSP1) motif (aa 147207) and a region rich in basic residues (aa 211263). Only the furinlike domains are needed for betacatenin stabilization. A putative nuclear localization signal at the Cterminus may allow some expression in the nucleus. - Proteine/Peptide
