Human P-Selectin / CD62P Protein, Fc Tag, Unconjugated
Biozol Catalog Number:
ABS-SEP-H5255-100UG
Supplier Catalog Number:
SEP-H5255-100ug
Alternative Catalog Number:
ABS-SEP-H5255-100UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
Pselectin (SELP) is also known as CD62 antigenlike family member P, granule membrane protein 140 (GMP140), leukocyteendothelial cell adhesion molecule 3 (LECAM3) and platelet activation dependent granuleexternal membrane protein (PADGEM). SELP functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called WeibelPalade bodies. In unactivated platelets SELP is stored in alphagranules. The primary ligand for SELP is Pselectin glycoprotein ligand1 (PSGL1) which is expressed on almost all leukocytes, although Pselectin also binds to heparan sulfate and fucoidan. Furthermore, SELP has a functional role in metastasis of tumor similar to Eselectin, which can help cancer cells invade into bloodstream for metastasis and provided locally with multiple growth factors respectively. - Proteine/Peptide
