Human Sonic Hedgehog / Shh (C24II) Protein, premium grade, Unconjugated, E. coli
Biozol Catalog Number:
ABS-SH7-H5116-20UG
Supplier Catalog Number:
SH7-H5116-20ug
Alternative Catalog Number:
ABS-SH7-H5116-20UG
Manufacturer:
AcroBiosystems
Host:
E. coli
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
Sonic hedgehog protein (SHH) is also known as HHG1, which belongs to the hedgehog family. SHH is expressed in fetal intestine, liver, lung, and kidney and not expressed in adult tissues. Sonic hedgehog protein can be cleavage into sonic hedgehog protein Nproduct and sonic hedgehog protein Cproduct by autolysis. SHH binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development. The Cterminal domain displays an autoproteolysis activity and a cholesterol transferase activity. The Nproduct is the active species in both local and longrange signaling, whereas the Cproduct has no signaling activity. - Proteine/Peptide
