Human STAT3 Protein, His Tag (MALS & SPR verified), Unconjugated, E. coli
Biozol Catalog Number:
ABS-ST3-H5149-500UG
Supplier Catalog Number:
ST3-H5149-500ug
Alternative Catalog Number:
ABS-ST3-H5149-500UG
Manufacturer:
AcroBiosystems
Host:
E. coli
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
Signal transducer and activator of transcription 3 (STAT3) regulates the expression of genes important for essential cellular processes including survival, proliferation, selfrenewal, angiogenesis, and immune response. As an early tumor diagnostic marker, it is considered that constitutive STAT3 activation is a sufficient factor to cause malignant transformation and tumor development in model systems. The classical IL6/STAT3 signaling pathway in cancer cells. IL6 binds to the membranebound IL6 receptor alpha (IL6R) and IL6 receptor beta (also known as gp130). The IL6/IL6R/gp130 complex activate the phosphorylation of JAKs, followed by STAT3 phosphorylation and activation. Then, phosphorylated STAT3 forms a homodimer and translocates into the nucleus to bind to the promotor region of target genes and activates target gene transcription. - Proteine/Peptide
