Human TDP-43 Protein, His Tag, Unconjugated, E. coli
Biozol Catalog Number:
ABS-TD3-H5145-25UG
Supplier Catalog Number:
TD3-H5145-25ug
Alternative Catalog Number:
ABS-TD3-H5145-25UG
Manufacturer:
AcroBiosystems
Host:
E. coli
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
TDP43, the transactive response (TAR)DNA binding Protein with a molecular weight of 43 KDa is encoded by TARDBP gene that located at the chromosome 1. It is a RNA/DNA binding protein that structurally resembles a typical hnRNP protein family member. involved in transcriptional regulation and RNA processing. It is linked to sporadic and familial amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP43 is predominantly nuclear, but it translocates to the cytoplasm under pathological conditions. Cytoplasmic accumulation, phosphorylation, ubiquitination and truncation of TDP43 are the main hallmarks of TDP43 proteinopathies. - Proteine/Peptide
