Biotinylated Human TEM8 / ANTXR1 (T118A) Protein, His,Avitag(TM) (MALS verified)
Biozol Catalog Number:
ABS-TE8-H82E4-200UG
Supplier Catalog Number:
TE8-H82E4-200ug
Alternative Catalog Number:
ABS-TE8-H82E4-200UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Biotin
This gene encodes a type I transmembrane protein and is a tumorspecific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008] - Proteine/Peptide
