Human TFPI Protein, His Tag (active enzyme), Unconjugated
Biozol Catalog Number:
ABS-TFI-H5226-50UG
Supplier Catalog Number:
TFI-H5226-50ug
Alternative Catalog Number:
ABS-TFI-H5226-50UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
Tissue factor pathway inhibitor (TFPI) is also known as Extrinsic pathway inhibitor (EPI), Lipoprotein associated coagulation inhibitor (LACI), is a plasma proteinase inhibitor synthesized by vascular endothelial cells and part of it is associated with glycosaminoglycans of these cells. TFPI is a singlechain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). TFPI is a secreted protein with a Nterminal acidic region, three Kunitz (K) domains separated with by two linker regions, and a Cterminal basic region. The first K domain inhibits coagulation factor VIIa complexed to tissue factor (TF), The second K domain inhibits factor Xa, The third K domain binds to heparin, The Cterminal basic region may have several functions. For example, it plays an important role in binding of TFPI to cell surfaces. - Proteine/Peptide
