Human TGF-beta RII / TGFBR2 Protein, His Tag (MALS verified), Unconjugated

Product Overview

• Article Name: Human TGF-beta RII / TGFBR2 Protein, His Tag (MALS verified), Unconjugated
• Biozol Catalog Number: ABS-TG2-H52H5-1MG
• Supplier Catalog Number: TG2-H52H5-1mg
• Alternative Catalog Number: ABS-TG2-H52H5-1MG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

TGFbeta receptor type2 (TGFBR2 or TGFR2) is also known as TGFbeta type II receptor, Transforming growth factorbeta receptor type II, TbetaRII, TGFbetaR2, which is a homodimer or heterohexamer, belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. TGFR2 / TGFBR2 binds TGFbeta1 / TGFB1 and TGFbeta3 / TGFB3 with high affinity and TGFbeta2 / TGFB2 with a much lower affinity. This type I I receptor forms a heterodimeric complex with type I receptor and is essential for signal transduction. Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. - Proteine/Peptide

Product Properties

• Molecular Weight: 17.4 kDa
• Tag: C-10*His
• NCBI: 37173
• Buffer: PBS, pH7.4
• Purity: 90%
• Form: Powder
• Target: TGF-beta RII

Images

Serial dilutions of Human TGF-beta RII, His Tag (Cat. No. TG2-H52H5) were added into Human Latent TGFB1, His Tag (Cat. No. TG1-H524x) : Biotinylated Human TGF-beta RII, His,Avitag (Cat. No. TG2-H82E4) binding reactions. The half maximal inhibitory concentration (IC50) is 0.39287 µg/mL (QC tested).

Human TGF-beta RII, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.