Biotinylated Mouse Thrombopoietin R Protein, His,Avitag(TM), Human
Biozol Catalog Number:
ABS-THR-M82E3-200UG
Supplier Catalog Number:
THR-M82E3-200ug
Alternative Catalog Number:
ABS-THR-M82E3-200UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Mouse
Conjugation:
Biotin
In 1990 an oncogene, vmpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, cmpl, was cloned. Sequence data revealed that cmpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of antisense oligodeoxynucleotides of cmpl inhibited megakaryocyte colony formation. The ligand for cmpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the cmpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPOR deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of nonreceptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008] - Proteine/Peptide
Biotinylated Mouse Thrombopoietin R Protein, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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