Human TIGIT Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified), Unconjugated

Product Overview

• Article Name: Human TIGIT Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified), Unconjugated
• Biozol Catalog Number: ABS-TIT-H5253-1MG
• Supplier Catalog Number: TIT-H5253-1mg
• Alternative Catalog Number: ABS-TIT-H5253-1MG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Tcell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as Vset and immunoglobulin domaincontaining protein 9 (VSIG9), Vset and transmembrane domaincontaining protein 3 (VSTM3),which belongs to singlepass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosinebased inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ Tcells and NK cells and is upregulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses Tcell activation by promoting the generation of mature immunoregulatory dendritic cells. - Proteine/Peptide

Product Properties

• Molecular Weight: 40.1 kDa
• Tag: C-mFc(mIgG2a)
• NCBI: 495
• Buffer: PBS, pH7.4
• Purity: 95%
• Form: Powder
• Target: TIGIT

Images

Immobilized Human CD155, Fc Tag (Cat. No. CD5-H5251) at 5 µg/mL (100 µL/well) can bind Human TIGIT, Mouse IgG2a Fc Tag (Cat. No. TIT-H5253) with a linear range of 0.5-4 ng/mL (QC tested).

Serial dilutions of TIGIT Antibody (1:2 serial dilutions, from 20 µg/mL to 0.0097 µg/mL) were added into Human TIGIT, Mouse IgG2a Fc Tag (Cat. No. TIT-H5253): Biotinylated Human Nectin-2, Fc,Avitag (Cat. No. CD2-H82F8) binding reactions. The assay was performed according to the above described protocol. Background was subtracted from data points before curve fitting.

TIT-H5253-1mg

Human TIGIT, Mouse IgG2a Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.