Human TIGIT Protein, His Tag, active dimer (MALS verified), Unconjugated

Product Overview

• Article Name: Human TIGIT Protein, His Tag, active dimer (MALS verified), Unconjugated
• Biozol Catalog Number: ABS-TIT-H52H5-1MG
• Supplier Catalog Number: TIT-H52H5-1mg
• Alternative Catalog Number: ABS-TIT-H52H5-1MG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Tcell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as Vset and immunoglobulin domaincontaining protein 9 (VSIG9), Vset and transmembrane domaincontaining protein 3 (VSTM3),which belongs to singlepass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosinebased inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ Tcells and NK cells and is upregulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses Tcell activation by promoting the generation of mature immunoregulatory dendritic cells. - Proteine/Peptide

Product Properties

• Molecular Weight: 28.8 kDa
• Tag: C-10*His
• NCBI: 495
• Buffer: PBS, pH7.4
• Purity: 90%
• Form: Powder
• Target: TIGIT

Images

Immobilized Human TIGIT, His Tag (Cat. No. TIT-H52H5) at 2 µg/mL (100 µL/well) can bind Human CD155, Fc Tag (Cat. No. CD5-H5251) with a linear range of 0.3-10 ng/mL (QC tested).

Immobilized Human TIGIT, His Tag (Cat. No. TIT-H52H5) at 1 µg/mL (100 µL/well) can bind Human Nectin-3, Fc Tag (Cat. No. PV3-H5255) with a linear range of 0.078-5 µg/mL (Routinely tested).

Human TIGIT, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

TIT-H52H5-1mg