Biotinylated Cynomolgus/Rhesus macaque TL1A / TNFSF15 Protein, Avitag(TM),His Tag (MALS verified), Human
Biozol Catalog Number:
ABS-TLA-C82E3-200UG
Supplier Catalog Number:
TLA-C82E3-200ug
Alternative Catalog Number:
ABS-TLA-C82E3-200UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Monkey
Conjugation:
Biotin
TL1A, also known as TNFSF15, is a member of the TNF superfamily. This type II transmembrane protein forms stable homotrimers via its TNF homology domain (THD) and is expressed in immune cells, including monocytes, macrophages, dendritic cells, and T cells, as well as nonimmune cells like synovial fibroblasts and endothelial cells. By binding to Death Receptor 3 (DR3), TL1A modulates proliferation, activation, apoptosis, and cytokine/chemokine production in effector cells, contributing to both innate and adaptive immune homeostasis. Dysregulated TL1A expression is implicated in autoimmune diseases such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease, making it a promising therapeutic target for conditions like ulcerative colitis and Crohns disease. - Proteine/Peptide
