Human TL1A / TNFSF15 Protein, His Tag (Monomer) (MALS verified), Unconjugated
Biozol Catalog Number:
ABS-TLA-H5246-1MG
Supplier Catalog Number:
TLA-H5246-1mg
Alternative Catalog Number:
ABS-TLA-H5246-1MG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
TNFlike cytokine 1A (TL1A) and its receptors, death receptor 3 (DR3) and decoy receptor 3 (DcR3) are members of the TNF and TNF receptor superfamilies of proteins, respectively. Binding of APCderived TL1A to lymphocytic DR3 provides costimulatory signals for activated lymphocytes. DR3 signaling affects not only the proliferative activity of and cytokine production by effector lymphocytes, but also critically influences the development and suppressive function of regulatory Tcells. Whereas, DcR3 restricts the function of the TL1A/DR3 complex: attenuating Tcell activation and downregulating the secretion of proinflammatory cytokines. Together with DR3 and DcR3, TL1A constitutes a cytokine system that actively interferes with the regulation of immune responses. - Proteine/Peptide
