Rabbit TL1A / TNFSF15 Protein, His Tag (MALS verified), Unconjugated, Human
Biozol Catalog Number:
ABS-TLA-R5243-1MG
Supplier Catalog Number:
TLA-R5243-1mg
Alternative Catalog Number:
ABS-TLA-R5243-1MG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Rabbit
Conjugation:
Unconjugated
TL1A, or Tumor Necrosis Factor Superfamily Member 15 (TNFSF15), also known as TL1 or VEGI, is a type II transmembrane protein belonging to the TNF ligand superfamily. It functions as a key regulator of both innate and adaptive immune responses. While expressed primarily in glandular, squamous, and specialized epithelial cells, TL1A is also found in immune cells such as macrophages and dendritic cells. Its Cterminal extracellular domain contains a TNF homology domain (THD), forming a homotrimeric structure. The functional receptor for TL1A is Death Receptor 3 (DR3, TNFRSF25), a type I transmembrane protein. TL1As signaling pathway is modulated by decoy receptor 3 (DcR3), which competes with DR3 for ligand binding. Upon binding to DR3, TL1A can activate proinflammatory signaling cascades (NFkappaB, MAPK, PI3K) or, alternatively, trigger TRADD dissociation and FADDmediated apoptosis via caspase8 and caspase3 activation. This dual signaling capacity makes TL1A a target of interest for the treatment of inflammatory bowel disease (IBD), allergic diseases, and autoimmune conditions. - Proteine/Peptide
Rabbit TL1A / TNFSF15 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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