TNFlike cytokine 1A (TL1A) and its receptors, death receptor 3 (DR3) and decoy receptor 3 (DcR3) are members of the TNF and TNF receptor superfamilies of proteins, respectively. Binding of APCderived TL1A to lymphocytic DR3 provides costimulatory signals for activated lymphocytes. DR3 signaling affects not only the proliferative activity of and cytokine production by effector lymphocytes, but also critically influences the development and suppressive function of regulatory Tcells. Whereas, DcR3 restricts the function of the TL1A/DR3 complex: attenuating Tcell activation and downregulating the secretion of proinflammatory cytokines. Together with DR3 and DcR3, TL1A constitutes a cytokine system that actively interferes with the regulation of immune responses. - Proteine/Peptide
Immobilized Rat TL1A Protein, His Tag (Cat. No. TLA-R5249) at 1 µg/mL (100 µL/well) can bind Monoclonal Anti-TL1A Antibody, Human IgG1 with a linear range of 0.03-1 ng/mL (QC tested).
Immobilized Human DcR3, Fc Tag (Cat. No. TNB-H5255) at 5 µg/mL (100 µL/well) can bind Rat TL1A Protein, His Tag (Cat. No. TLA-R5249) with a linear range of 0.06-4 ng/mL (Routinely tested).
Rat TL1A Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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