Biotinylated Human CD40 / TNFRSF5 Protein, Fc,Avitag(TM) (MALS verified)
Biozol Catalog Number:
ABS-TN5-H82F9-200UG
Supplier Catalog Number:
TN5-H82F9-200ug
Alternative Catalog Number:
ABS-TN5-H82F9-200UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Biotin
CD40 is also known as TNFRSF5, Bp50, CDW40, MGC9013, TNFRSF5 and p50, is a member of the TNF receptor superfamily which are single transmembranespanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T celldependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 contains 4 cysteinerich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. The extracellular domain has the cysteinerich repeat regions, which are characteristic for many of the receptors of the TNF superfamily. Interaction of CD40 with its ligand, CD40L, leads to aggregation of CD40 molecules,which in turn interact with cytoplasmic components to initiate signaling pathways. Early studies on the CD40CD40L system revealed its role in humoral immunity. Defects in CD40 result in hyperIgM immunodeficiency type 3 (HIGM3), an autosomal recessive disorder characterized by an inability of B cells to undergo isotype switching, as well as an inability to mount an antibodyspecific immune response, and a lack of germinal center formation. - Proteine/Peptide
