Human TrkA / NTRK1 (33-417) Protein, Mouse IgG2a Fc Tag, Unconjugated

Product Overview

• Article Name: Human TrkA / NTRK1 (33-417) Protein, Mouse IgG2a Fc Tag, Unconjugated
• Biozol Catalog Number: ABS-TRA-H5259-1MG
• Supplier Catalog Number: TRA-H5259-1mg
• Alternative Catalog Number: ABS-TRA-H5259-1MG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligandbinding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. - Proteine/Peptide

Product Properties

• Molecular Weight: 68.2 kDa
• Tag: C-mFc(mIgG2a)
• NCBI: 04629
• Buffer: Tris with Glycine, Arginine and NaCl, pH7.5
• Purity: 95%
• Form: Powder
• Target: TrkA

Images

Immobilized Human Beta-NGF Protein, premium grade (Cat. No. BEF-H5214) at 1 µg/mL (100 µL/well) can bind Human TrkA (33-417), Mouse IgG2a Fc Tag (Cat. No. TRA-H5259) with a linear range of 0.1-16 ng/mL (Routinely tested).

Human TrkA (33-417), Mouse IgG2a Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.