Tyrosineprotein kinase receptor TYRO3 is also known as Tyrosineprotein kinase BYK, DTK, RSE, SKY, TIF, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. TYRO3 regulates many physiological processes including cell survival, migration and differentiation. TYRO3 activates the AKT survival pathway, including nuclear translocation of NFkappaB and upregulation of transcription of NFkappaBregulated genes. TYRO3 interacts (via Nterminus) with extracellular ligands TULP1 and GAS6 By similarity and also interacts with PIK3R1, this interaction increases PI3kinase activity. - Proteine/Peptide
