The verylowdensitylipoprotein receptor (VLDLR) is a lipoprotein receptor that shows considerable similarity to the lowdensitylipoprotein receptor. VLDL R is a 130 kDa type I transmembrane protein in the LDL receptor family that plays a significant role in lipid metabolism and in nervous system development and function .This receptor has been suggested to be important for the metabolism of apoproteinEcontaining triacylglycerolrich lipoproteins, such as verylowdensitylipoprotein (VLDL), betamigrating VLDL and intermediatedensity lipoprotein. It is also one of the receptors of reelin, an extracellular matrix protein which regulates the processes of neuronal migration and synaptic plasticity. In humans, the VLDLR is encoded by the VLDLR gene. A rare neurological disorder first described in the 1970s under the name disequilibrium syndrome is now considered to be caused by the disruption of VLDLR gene. The disorder was renamed VLDLRassociated cerebellar hypoplasia (VLDLRCH) after a 2005 study. It is associated with parental consanguinity and found in secluded communities such as the Hutterites. VLDLRCH is one of the two known genetic disorders caused by a disruption of reelin signaling pathway, along with NormanRoberts syndrome. - Proteine/Peptide
Immobilized Human VLDL R, His Tag (Cat. No. VLR-H5227) at 5 µg/mL (100 µL/well) can bind Biotinylated Human PCSK9,Avitag,HisTag (Cat. No. PC9-H82E7) with a linear range of 10-156 ng/mL (QC tested).
Human VLDL R, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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