Human WEE1 Protein, His Tag (active enzyme), Unconjugated, Insect
Biozol Catalog Number:
ABS-WE1-H5543-1MG
Supplier Catalog Number:
WE1-H5543-1mg
Alternative Catalog Number:
ABS-WE1-H5543-1MG
Manufacturer:
AcroBiosystems
Host:
Insect
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
WEE1 is a serine/threonine protein kinase that acts as a critical regulator of the cell cycle, particularly at the G2/M checkpoint. It inhibits cell cycle progression by phosphorylating and inactivating CDK1 (CyclinDependent Kinase 1) at Tyr15, thereby preventing premature entry into mitosis and allowing time for DNA repair.Originally identified in fission yeast, WEE1 is highly conserved in mammals and plays a key role in maintaining genomic stability. Dysregulation of WEE1 is linked to cancer progression, as its overexpression in tumors (e.g., ovarian, breast, pancreatic cancers) supports cancer cell survival by enabling DNA damage tolerance. This dependency makes WEE1 a promising therapeutic target, especially in p53mutant cancers where inhibiting WEE1 induces synthetic lethality by forcing cells with unrepaired DNA into catastrophic mitosis. - Proteine/Peptide
