Anti-CaSR Antibody, Rabbit, Polyclonal

Product Overview

• Article Name: Anti-CaSR Antibody, Rabbit, Polyclonal
• Biozol Catalog Number: ABT-AN1327
• Supplier Catalog Number: AN1327
• Alternative Catalog Number: ABT-AN1327-100UL
• Manufacturer: Abcepta
• Host: Rabbit
• Category: Antikörper
• Alternative Names: Ca sensing receptor antibody, Ca2+ sensing receptor 1 antibody, Ca2+ sensing receptor antibody, Calcium sensing receptor antibody, CAR antibody, CaSR antibody, CASR_HUMAN antibody, Extracellular calcium sensing receptor antibody, Extracellular calcium sensing receptor [Precursor] antibody, Extracellular calcium-sensing receptor antibody, FHH antibody, FIH antibody, GPRC2A antibody, HHC antibody, HHC1 antibody, Hypocalciuric hypercalcemia 1 antibody, Hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism antibody, MGC138441 antibody, NSHPT antibody, Parathyroid Ca(2+) sensing receptor 1 antibody, Parathyroid Cell calcium sensing receptor antibody, Parathyroid Cell calcium-sensing receptor antibody, PCAR 1 antibody, PCaR1 antibody

Product Description

Calcium sensing receptor, CaSR, is a unique G protein-coupled receptor activated by extracellular Ca2+, Mg2+, Sr2+, Mn2+, Ba2+, Ni2+, Al2+, Gd3+, amino acids, polyamines, pH and ionic strength (Quinn, S.J. et al., 1998). CaSR is a cell surface dimer located in the caveolin-rich plasma membrane domains (Kifor, O., et al., 1998). CaSR tightly regulates extracellular calcium levels to avoid hyper/hypo-calcemia through complex interactions with PTH, calcitonin, and vitamin D by balancing their effects on the parathyroid glands, bone, kidney, and intestine (Diaz-Soto, G. et al., 2016). Additionally, CaSR has been identified in the nervous system and recent studies suggest CaSR as a direct target of reducing Abeta42 secretion that may contribute to Alzheimers Disease (Armato, U., et al., 2013). Recent studies have shown CaSR negatively impacts the formation and progression of neuroblastomas by calcium exposure leading NB cells overexpressing CaSR to undergo apoptosis by means of activating ERK1/2 (Casala, C., et al., 2013).

Product Properties

• Clonality: Polyclonal
• Molecular Weight: 120868
• NCBI: 24247
• UniProt: P48442
• Form: Antigen Affinity Purified from Pooled Serum
• Target: Calcium sensing receptor, CaSR, is a unique G protein-coupled receptor activated by extracellular Ca2+, Mg2+, Sr2+, Mn2+, Ba2+, Ni2+, Al2+, Gd3+, amino acids, polyamines, pH and ionic strength (Quinn, S.J. et al., 1998). CaSR is a cell surface dimer locat