Anti-Neuropilin-1 (a1 CUB Domain) Antibody, IgG1, Clone: [M534], Mouse, Monoclonal
Catalog Number:
ABT-AN1856
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| Article Name: | Anti-Neuropilin-1 (a1 CUB Domain) Antibody, IgG1, Clone: [M534], Mouse, Monoclonal |
| Biozol Catalog Number: | ABT-AN1856 |
| Supplier Catalog Number: | AN1856 |
| Alternative Catalog Number: | ABT-AN1856-100UL |
| Manufacturer: | Abcepta |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | IHC, WB |
| Alternative Names: | NRP1, VEGF 165, VEGFR |
| Neuropilins are transmembrane proteins that contain two CUB domains (a1 and a2), two coagulation factor-like domains (b1 and b2), and a MAM domain in the extracellular region. These proteins have short cytoplasmic domains that include a PDZ-binding motif. The neuropilin (NRP) family includes NRP-1, NRP-2A, and NRP-2B. NRP-1 has been implicated as a receptor involved in axon guidance and VEGF signaling. NRP-1 mediates activation of intracellular signaling pathways through interaction with its co-receptors, Plexin-A1 and VEGFRs. The expression of NRP-1, along with the co-receptor Plexin-A1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3A-containing regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin-A1 and Neuropilin-1, may have significant roles in axon regeneration after neuronal injury. |
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