Anti-Paxillin (Tyr-118), Phosphospecific Antibody, Rabbit, Polyclonal
Catalog Number:
ABT-AN1889
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| Article Name: | Anti-Paxillin (Tyr-118), Phosphospecific Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ABT-AN1889 |
| Supplier Catalog Number: | AN1889 |
| Alternative Catalog Number: | ABT-AN1889-100UL |
| Manufacturer: | Abcepta |
| Host: | Rabbit |
| Category: | Antikörper |
| Species Reactivity: | Drosophila |
| Paxillin is involved in focal adhesion formation during cell adhesion and migration. Paxillin contains LD motifs, LIM domains, and an SH3- and SH2-binding domain that participate in a variety of protein-protein interactions with kinases, GTPase-activating proteins, and cytoskeletal proteins. Phosphorylation of paxillin occurs at both tyrosine and serine sites. Tyrosine phosphorylation of paxillin occurs in response to growth factors, neuropeptides, and integrins. The major sites of tyrosine phosphorylation include Tyr-31 and Tyr-118. Both of these sites may be involved in Crk binding to paxillin during integrin-mediated cell adhesion. These sites may provide docking motifs for recruitment of other signaling molecules to focal adhesions. |
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