Anti-Paxillin (Thr-538), Phosphospecific Antibody, Rabbit, Polyclonal
Catalog Number:
ABT-AN1891
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| Article Name: | Anti-Paxillin (Thr-538), Phosphospecific Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ABT-AN1891 |
| Supplier Catalog Number: | AN1891 |
| Alternative Catalog Number: | ABT-AN1891-100UL |
| Manufacturer: | Abcepta |
| Host: | Rabbit |
| Category: | Antikörper |
| Species Reactivity: | Drosophila |
| Paxillin, a focal adhesion protein, is involved in focal adhesion formation during cell adhesion and migration. Paxillin contains LD motifs, LIM domains, and SH3-/SH2-binding domains that participate in a variety of protein-protein interactions with kinases, GTPase-activating proteins, and cytoskeletal proteins. Phosphorylation of paxillin occurs at tyrosine, threonine, and serine sites. Serine and threonine phosphorylation of paxillin occur in response to growth-factor activation, PKC activators, and fibronectins. Phosphorylation of Ser-85, Ser-178, and Thr-538 may be important sites for regulating paxillin activity. Paxillin phosphorylation of Thr-538 occurs in response to TPA-activated PKCs in vitro, and this phosphorylation may contribute to dissolution of the actin cytoskeleton and redistribution of LFA-1 integrins in vivo. |
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