Anti-PLCgamma1 (Tyr-775), Phosphospecific Antibody, Rabbit, Polyclonal
Catalog Number:
ABT-AN1910
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| Article Name: | Anti-PLCgamma1 (Tyr-775), Phosphospecific Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ABT-AN1910 |
| Supplier Catalog Number: | AN1910 |
| Alternative Catalog Number: | ABT-AN1910-100UL |
| Manufacturer: | Abcepta |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | IHC, WB |
| Alternative Names: | Phospholipase C gamma1, phosphodiesterase |
| Phosphoinositide-specific phospholipase C (PLC) plays a significant role in transmembrane signaling. In response to extracellular stimuli such as hormones, growth factors, and neurotransmitters, PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to generate two secondary messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). At least four families of PLCs have been identified: PLCbeta, PLCgamma, PLCdelta, and PLCepsilon. Phosphorylation is one of the key mechanisms that regulates the activity of PLC. PLCdelta is activated by both receptor and nonreceptor tyrosine kinases. PLCgamma1 forms a complex with EGF and PDGF receptors, which leads to phosphorylation at tyrosine 771, 783, and 1245. In addition, antigen receptor-induced activation of PLCgamma1 leads to phosphorylation at both Tyr-775 and Tyr-783. These two sites are equally important for activation of enzymatic activity. |
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