Anti-Semaphorin-3F (C-terminal region) Antibody, Rabbit, Polyclonal
Catalog Number:
ABT-AN1947
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| Article Name: | Anti-Semaphorin-3F (C-terminal region) Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ABT-AN1947 |
| Supplier Catalog Number: | AN1947 |
| Alternative Catalog Number: | ABT-AN1947-100UL |
| Manufacturer: | Abcepta |
| Host: | Rabbit |
| Category: | Antikörper |
| One family of inhibitory axon guidance molecules is the semaphorins. The semaphorins include secreted, transmembrane, and GPI-anchored extracellular molecules that have been implicated in neuron development, vascular disease, and tumor progression. There are eight classes of semaphorin genes, all of which are characterized by a conserved 500 amino acid, cystine-rich Sema domain. Semaphorin 3F (Sema-3F) is a class III secreted semaphorin that binds with high affinity to Neuropilin-2, and low affinity to Neuropilin-1. During peripheral and central nervous system development, Sema-3F has critical roles in axon guidance and dendrite outgrowth. Sema-3F has also been shown to inhibit angiogenesis by manipulating VEGFR function and decreasing blood vessel density. In cancers, Sema-3F induces a poorly vascularized, encapsulated, non-metastatic phenotype through chemorepulsion of endothelial cells in melanoma, while Sema-3F disrupts intercellular contacts of MCF7 breast cancer cells through delocalization of E-cadherin and beta-catenin. Thus, Sema-3F may have important roles in axon guidance, angiogenesis, and tumor progression |
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