Anti-IKAP (C-terminal) Antibody, Rabbit, Polyclonal
Catalog Number:
ABT-AN2066
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| Article Name: | Anti-IKAP (C-terminal) Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ABT-AN2066 |
| Supplier Catalog Number: | AN2066 |
| Alternative Catalog Number: | ABT-AN2066-100UL |
| Manufacturer: | Abcepta |
| Host: | Rabbit |
| Category: | Antikörper |
| Alternative Names: | Elongator complex protein 1, ELP1, DYS, IkappaB kinase complex associated protein, ikbkap, IKI3, p150, TOT1 |
| The transcription factor NF-kappaB coordinates the activation of numerous genes in response to pathogens and pro-inflammatory cytokines, and is, therefore, vital in the development of acute and chronic inflammatory diseases. NF-kappaB is activated by cytokine-activated IKB kinases (IKKs), IKK-alpha and IKK-beta isozymes are found in large complexes These large, interleukin-1-inducible IKK complexes have been found to contain a new protein, termed IKK-complex-associated protein (IKAP), which can bind NIK and IKKs and assemble them into an active kinase complex. IKAP is a scaffold protein and a regulator for three different kinases involved in pro-inflammatory cytokine signaling. |
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