ELF3, E74 like factor 3, Epithelial restricted with serine box, Epithelium specific Ets transcription factor 1, Ets domain transcription factor serine box epithelial specific, EPR1, ERT
ESE-1 (for epithelium-specific Ets), is a novel, highly tissue-restricted member of the ets transcription factor/oncogene family, which has features distinct from those of any other ets-related factor. ESE-1 binds with high affinity to and transactivates the ets binding site in the promoter of the keratinocyte terminal differentiation marker gene, SPRR2A. ESE-1 is a critical regulator of epithelial cell differentiation.