Anti-FBXW7 (hCdc4) Antibody, Rabbit, Polyclonal
Catalog Number:
ABT-AN2106
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| Article Name: | Anti-FBXW7 (hCdc4) Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ABT-AN2106 |
| Supplier Catalog Number: | AN2106 |
| Alternative Catalog Number: | ABT-AN2106-100UL |
| Manufacturer: | Abcepta |
| Host: | Rabbit |
| Category: | Antikörper |
| Alternative Names: | Cdc4, FBXW7, Archipelago, AGO, F box and WD 40 domain protein 7, FBW7, SEL10 |
| Cyclin E, one of the activators of the cyclin-dependent kinase Cdk2, is critical for the initiation of DNA replication and other S-phase functions. The proper timing and amplitude of cyclin E expression seem to be important, because elevated levels of cyclin E have been associated with a variety of malignancies and constitutive expression of cyclin E leads to genomic instability. Phosphorylated cyclin E depends on the novel human gene, hCdc4, that was found to be mutated in a cell line derived from breast cancer that expressed extremely high levels of cyclin E. |
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