Anti-PUMA Antibody, Rabbit, Polyclonal
Catalog Number:
ABT-AN2117
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| Article Name: | Anti-PUMA Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ABT-AN2117 |
| Supplier Catalog Number: | AN2117 |
| Alternative Catalog Number: | ABT-AN2117-100UL |
| Manufacturer: | Abcepta |
| Host: | Rabbit |
| Category: | Antikörper |
| Alternative Names: | BBC3, Bcl-2-binding component 3, isoforms 1/2, JFY1, p53 up-regulated modulator of apoptosis |
| A novel gene PUMA (p53 upregulated modulator of apoptosis) is a target for activation by the p53 tumor-suppressor gene. p53 functions as a transcriptional activator, and influences p53-inducible genes that play a role in the induction of apoptosis in response to p53. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway. |
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