CDKN1A Antibody (C-term), Rabbit, Polyclonal

Product Overview

• Article Name: CDKN1A Antibody (C-term), Rabbit, Polyclonal
• Biozol Catalog Number: ABT-AP20643C
• Supplier Catalog Number: AP20643c
• Alternative Catalog Number: ABT-AP20643C-400UL
• Manufacturer: Abcepta
• Host: Rabbit
• Category: Antikörper
• Application: IF, IHC-P, WB
• Species Reactivity: Human, Mouse
• Alternative Names: Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, MDA-6, p21, CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1

Product Description

May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.

Product Properties

• Clonality: Polyclonal
• Clone Designation: [RB43821]
• Molecular Weight: 18119
• NCBI: 1026
• UniProt: P38936
• Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Target: This CDKN1A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 133-164 amino acids from the C-terminal region of human CDKN1A.
• Antibody Type: Polyclonal Antibody