LPR1(S4520) Antibody, Clone: [R02614NP], Rabbit, Polyclonal

Product Overview

• Article Name: LPR1(S4520) Antibody, Clone: [R02614NP], Rabbit, Polyclonal
• Biozol Catalog Number: ABT-AP22410A
• Supplier Catalog Number: AP22410a
• Alternative Catalog Number: ABT-AP22410A-200UL
• Manufacturer: Abcepta
• Host: Rabbit
• Category: Antikörper
• Application: WB
• Alternative Names: Prolow-density lipoprotein receptor-related protein 1, LRP-1, Alpha-2-macroglobulin receptor, A2MR, Apolipoprotein E receptor, APOER, CD91, Low-density lipoprotein receptor-related protein 1 85 kDa subunit, LRP-85, Low-density lipoprotein receptor-related protein 1 515 kDa subunit, LRP-515, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRPICD, LRP1 (HGNC:6692), A2MR, APR

Product Description

Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2- macroglobulin receptor (PubMed:26142438, PubMed:1702392). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553).

Product Properties

• Clonality: Polyclonal
• Clone Designation: [R02614NP]
• Molecular Weight: 504606
• NCBI: 4035
• UniProt: Q07954
• Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Target: This LPR1(S4520) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from the human region of human LPR1(S4520).