WT1 antibody, Clone: [R03989], Rabbit, Polyclonal

Product Overview

• Article Name: WT1 antibody, Clone: [R03989], Rabbit, Polyclonal
• Biozol Catalog Number: ABT-AP22423A-EV
• Supplier Catalog Number: AP22423a-ev
• Alternative Catalog Number: ABT-AP22423A-EV-50UL
• Manufacturer: Abcepta
• Host: Rabbit
• Category: Antikörper
• Application: WB
• Species Reactivity: Human
• Alternative Names: Wilms tumor protein, WT33, WT1

Product Description

Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5-GCG(T/G)GGGCG-3 (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921).

Product Properties

• Clonality: Polyclonal
• Clone Designation: [R03989]
• Molecular Weight: 49188
• NCBI: 7490
• UniProt: P19544
• Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Target: This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from human.