CD3E antibody (C-term), Clone: [R03318], Rabbit, Polyclonal

Product Overview

• Article Name: CD3E antibody (C-term), Clone: [R03318], Rabbit, Polyclonal
• Biozol Catalog Number: ABT-AP22441B
• Supplier Catalog Number: AP22441b
• Alternative Catalog Number: ABT-AP22441B-200UL
• Manufacturer: Abcepta
• Host: Rabbit
• Category: Antikörper
• Application: WB
• Species Reactivity: Mouse
• Alternative Names: T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T3E

Product Description

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down- regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128).

Product Properties

• Clonality: Polyclonal
• Clone Designation: [R03318]
• Molecular Weight: 23147
• NCBI: 916
• UniProt: P07766
• Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Target: This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from human.