beclin1(S64)Antibody, Clone: [R04427NP], Rabbit, Polyclonal

Product Overview

• Article Name: beclin1(S64)Antibody, Clone: [R04427NP], Rabbit, Polyclonal
• Biozol Catalog Number: ABT-AP22477A-EV
• Supplier Catalog Number: AP22477a-ev
• Alternative Catalog Number: ABT-AP22477A-EV-50UL
• Manufacturer: Abcepta
• Host: Rabbit
• Category: Antikörper
• Application: WB
• Species Reactivity: Human
• Alternative Names: Beclin-1, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197, Beclin-1-C 35 kDa, Beclin-1-C 37 kDa, BECN1, GT197

Product Description

Plays a central role in autophagy (PubMed:18570871, PubMed:21358617, PubMed:23184933, PubMed:23974797, PubMed:25484083, PubMed:28445460, PubMed:37776275). Acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate, different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123, PubMed:23974797, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). May play a role in antiviral host defense.

Product Properties

• Clonality: Polyclonal
• Clone Designation: [R04427NP]
• Molecular Weight: 51896
• NCBI: 8678
• UniProt: Q14457
• Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Target: This beclin1(S64) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from the human region of human beclin1(S64).