RAD9(S277)Antibody, Clone: [R04540NP], Rabbit, Polyclonal

Product Overview

• Article Name: RAD9(S277)Antibody, Clone: [R04540NP], Rabbit, Polyclonal
• Biozol Catalog Number: ABT-AP22478A
• Supplier Catalog Number: AP22478a
• Alternative Catalog Number: ABT-AP22478A-200UL
• Manufacturer: Abcepta
• Host: Rabbit
• Category: Antikörper
• Application: WB
• Species Reactivity: Human
• Alternative Names: Cell cycle checkpoint control protein RAD9A, hRAD9, 3.1.11.2, DNA repair exonuclease rad9 homolog A, RAD9A

Product Description

Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10713044, PubMed:17575048, PubMed:20545769, PubMed:21659603, PubMed:31135337). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17- replication factor C (RFC) clamp loader complex (PubMed:21659603). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:21659603). The 9-1- 1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds, endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths, and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:21659603). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). RAD9A possesses 3->5 double stranded DNA exonuclease activity (PubMed:10713044).

Product Properties

• Clonality: Polyclonal
• Clone Designation: [R04540NP]
• Molecular Weight: 42547
• NCBI: 5883
• UniProt: Q99638
• Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Target: This RAD9(S277) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from the human region of human RAD9(S277).