GANP Antibody, Rabbit, Polyclonal
Catalog Number:
ABT-AP51336
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| Article Name: | GANP Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ABT-AP51336 |
| Supplier Catalog Number: | AP51336 |
| Alternative Catalog Number: | ABT-AP51336-100UL |
| Manufacturer: | Abcepta |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | ELISA, IHC-P, WB |
| Species Reactivity: | Human, Mouse, Rat |
| Alternative Names: | Germinal-center associated nuclear protein, GANP, 80 kDa MCM3-associated protein, MCM3 acetylating protein, MCM3AP, 231-, MCM3 acetyltransferase, MCM3AP, GANP, KIAA0572, MAP80 |
| Isoform GANP: Essential for the generation of high- affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation- dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells (By similarity). Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. |
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