NEURL1 Antibody, Rabbit, Polyclonal

Product Overview

• Article Name: NEURL1 Antibody, Rabbit, Polyclonal
• Biozol Catalog Number: ABT-AP51384
• Supplier Catalog Number: AP51384
• Alternative Catalog Number: ABT-AP51384-100UL
• Manufacturer: Abcepta
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, ICC, IHC-P, WB
• Species Reactivity: Human
• Alternative Names: E3 ubiquitin-protein ligase NEURL1, 632-, Neuralized-like protein 1A, h-neu, h-neuralized 1, RING finger protein 67, NEURL1, NEURL, NEURL1A, RNF67

Product Description

Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element- binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor, inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.

Product Properties

• Clonality: Polyclonal
• NCBI: 9148
• UniProt: O76050