NOTCH2 Antibody, Rabbit, Polyclonal

Product Overview

• Article Name: NOTCH2 Antibody, Rabbit, Polyclonal
• Biozol Catalog Number: ABT-AP51394
• Supplier Catalog Number: AP51394
• Alternative Catalog Number: ABT-AP51394-100UL
• Manufacturer: Abcepta
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, ICC, IHC-P, WB
• Species Reactivity: Human, Mouse, Rat
• Alternative Names: Neurogenic locus notch homolog protein 2, Notch 2, hN2, Notch 2 extracellular truncation, Notch 2 intracellular domain, NOTCH2

Product Description

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation.

Product Properties

• Clonality: Polyclonal
• NCBI: 4853
• UniProt: Q04721