Retinoblastoma-like protein 2, 130 kDa retinoblastoma-associated protein, p130, Retinoblastoma-related protein 2, RBR-2, pRb2, RBL2, RB2
RBL2 is a key regulator of entry into cell division. The protein is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. It recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. It controls histone H4 Lys-20 trimethylation. It probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters.
Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Target:
The synthetic peptide sequence used to generate the antibody AP6543c was selected from the Center region of human RBL2/p130. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
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