Microtubule-associated protein RP/EB family member 1, APC-binding protein EB1, End-binding protein 1, EB1, MAPRE1
The protein encoded by this gene was first identified byits binding to the APC protein which is often mutated in familialand sporadic forms of colorectal cancer. This protein localizes tomicrotubules, especially the growing ends, in interphase cells.During mitosis, the protein is associated with the centrosomes andspindle microtubules. The protein also associates with componentsof the dynactin complex and the intermediate chain of cytoplasmicdynein. Because of these associations, it is thought that thisprotein is involved in the regulation of microtubule structures andchromosome stability. This gene is a member of the RP/EB family.