Methylosome protein 50, MEP-50, Androgen receptor cofactor p44, WD repeat-containing protein 77, p44/Mep50, WDR77, MEP50, WD45
WDR77 is a component of the 20S PRMT5 (MIM604045)-containing methyltransferase complex, which modifiesspecific arginines to dimethylarginines in several spliceosomal Smproteins (see MIM 601061). This modification targets Sm proteins tothe survival of motor neurons (SMN) complex (see MIM 600354) forassembly into small nuclear ribonucleoprotein core particles(Friesen et al., 2002 [PubMed 11756452]).