Eukaryotic initiation factor-2B (EIF2B) is a GTP exchange protein essential for protein synthesis. It consists of alpha (EIF2B1, MIM 606686), beta (EIF2B2), gamma (EIF2B3, MIM 606273), delta (EIF2B4, MIM 606687), and epsilon (EIF2B5, MIM 603945) subunits. EIF2B activates its EIF2 (see MIM 603907) substrate by exchanging EIF2-bound GDP for GTP.
Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Target:
The synthetic peptide sequence used to generate the antibody AP6781b was selected from the C-term region of human EIF2B2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
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