Activin Receptor Type IA (ACVR1) Antibody (Center R147) Blocking peptide

Product Overview

• Article Name: Activin Receptor Type IA (ACVR1) Antibody (Center R147) Blocking peptide
• Biozol Catalog Number: ABT-BP7806C
• Supplier Catalog Number: BP7806c
• Alternative Catalog Number: ABT-BP7806C-500UG
• Manufacturer: Abcepta
• Category: Proteine/Peptide
• Alternative Names: Activin receptor type-1, Activin receptor type I, ACTR-I, Activin receptor-like kinase 2, ALK-2, Serine/threonine-protein kinase receptor R1, SKR1, TGF-B superfamily receptor type I, TSR-I, ACVR1, ACVRLK2

Product Description

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 (activin A type I receptor) signals a particular transcriptional response in concert with activin type II receptors.

Product Properties

• NCBI: 90
• UniProt: Q04771
• Form: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
• Target: The synthetic peptide sequence used to generate the antibody AP7806c was selected from the Center region of human ACVR1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.