Protein max, Class D basic helix-loop-helix protein 4, bHLHd4, Myc-associated factor X, MAX, BHLHD4
MAX is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation.
Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Target:
The synthetic peptide sequence used to generate the antibody AP7827a was selected from the S11 region of human MAX. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
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