Dual specificity protein phosphatase 16, Mitogen-activated protein kinase phosphatase 7, MAP kinase phosphatase 7, MKP-7, DUSP16, KIAA1700, MKP7
DUSP16 is involved in the inactivation of MAP kinases. The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis. For full activation of MAPKs, dual-specificity kinases phosphorylate both threonine and tyrosine residues in MAPK TXY motifs. MKPs are dual-specificity phosphatases that dephosphorylate the TXY motif, thereby negatively regulating MAPK activity.
Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Target:
The synthetic peptide sequence used to generate the antibody AP8458b was selected from the C-term region of human DUSP16. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
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