PPP4C belongs to the PPP phosphatase family, PP-X subfamily, and may participate in microtubule organization. Both overexpression and RNA interference experiments indicate that HDAC3 activity is inversely proportional to the cellular abundance of PPP4C. The PPP4C gene maps to chromosome 16p12-p11. Several translocations associated with acute leukemias have been mapped to this region of chromosome 16p.
Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Target:
The synthetic peptide sequence used to generate the antibody AP8475a was selected from the N-term region of human PPP4C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
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