Myeloid differentiation primary response protein MyD88, MYD88
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. It acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response and increases IL-8 transcription. It may be involved in myeloid differentiation.
Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Target:
The synthetic peptide sequence used to generate the antibody AP8521c was selected from the Center region of human MyD88. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
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