HSPC142 Antibody (N-term) Blocking peptide

Product Overview

• Article Name: HSPC142 Antibody (N-term) Blocking peptide
• Biozol Catalog Number: ABT-BP8573A
• Supplier Catalog Number: BP8573a
• Alternative Catalog Number: ABT-BP8573A-500UG
• Manufacturer: Abcepta
• Category: Proteine/Peptide
• Alternative Names: BRISC and BRCA1-A complex member 1, Mediator of RAP80 interactions and targeting subunit of 40 kDa, New component of the BRCA1-A complex, BABAM1, C19orf62, MERIT40, NBA1

Product Description

HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes Lys-63-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes Lys-63-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves Lys-63-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the Lys-63-linked deubiquitinase activity mediated by BRCC3/BRCC36. component

Product Properties

• NCBI: 29086
• UniProt: Q9NWV8
• Form: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.